Sore throats are a frequent concern in pharmacy consultations, often caused by viral infections, bacterial infections, or environmental irritants.1 Pharmacists are uniquely positioned to guide patients through the progression of sore throat symptoms, offering practical, evidence-based advice. Lozenges can provide effective relief at various stages of sore throat discomfort, from early irritation to more severe pain.2,3
CAUSES OF SORE THROATS
Sore throats are commonly caused by viral infections, such as the common cold or flu, and bacterial infections, such as strep throat. Environmental factors, including dry air, allergens, and irritants like smoke, can also contribute to throat discomfort. These causes lead to inflammation of the pharynx or larynx, resulting in the characteristic symptoms of a sore throat.1
EARLY SYMPTOMS: DRYNESS AND IRRITATION
Sore throats often begin with mild symptoms such as dryness, irritation, or scratchiness. These early signs are typically linked to inflammation caused by infections or exposure to environmental irritants. Patients may describe these sensations as uncomfortable but not yet painful.1,2
Lozenges can help alleviate these early symptoms by stimulating saliva production, which moistens the throat and reduces dryness and irritation. This is particularly useful for patients experiencing discomfort due to dry air or allergens.2,3
ESCALATING PAIN AND INFLAMMATION
As a sore throat progresses, symptoms can worsen, leading to more pronounced pain and difficulty swallowing. This stage is often accompanied by redness and swelling in the throat, which can make eating and drinking uncomfortable. Infections, particularly bacterial ones like strep throat, may exacerbate these symptoms.1
Medicated lozenges can provide relief during this stage. Many contain local anaesthetics, antiseptics, or anti-inflammatory agents that target pain and reduce inflammation. These ingredients offer fast-acting relief, making lozenges a convenient option for patients seeking immediate comfort.2 Pharmacists can emphasise the importance of using lozenges as directed to maximise their benefits while avoiding overuse.
USEFUL INGREDIENTS IN SORE THROAT LOZENGES
Certain active ingredients in lozenges can provide targeted relief for sore throat symptoms. Benzydamine hydrochloride, an anti-inflammatory and analgesic agent, helps reduce pain and inflammation associated with sore throats. It is particularly effective in alleviating sore throat and related discomfort caused by upper respiratory infections.5-7
Cetylpyridinium chloride, an antiseptic, works by targeting bacteria and viruses in the throat, helping to reduce microbial load and prevent further irritation.8-10
Lozenges containing this combination have been shown to significantly reduce pain and inflammation, making them a valuable option for patients seeking effective sore throat relief.10
ROLE OF FAST-ACTING, ON-THE-GO RELIEF
One of the key advantages of lozenges is their portability and ease of use. Unlike other remedies that may require preparation, lozenges can be used anytime, anywhere, making them ideal for busy individuals. This aligns with the practical needs of patients who may not have the time or resources for more involved treatments.
In addition to lozenges, pharmacists can recommend complementary self-care measures to support recovery. Staying hydrated is essential, as it helps keep the throat moist and reduces irritation. Gargling with warm salt water can also soothe the throat and reduce swelling. Patients should be advised to avoid irritants like smoke, which can worsen symptoms.4
CONCLUSION
Sore throats present a range of challenges that require thoughtful, patient-centric solutions. Lozenges offer a versatile and effective option for managing symptoms such as dryness, irritation, swelling and pain, providing fast-acting, on-the-go relief. By guiding patients through the sore throat journey, pharmacists can make a meaningful difference in their comfort and recovery.
REFERENCES
- Mayo Clinic Staff. Sore Throat: Symptoms and Causes. Mayo Clinic. 12 April 2025. Available from: https://www.mayoclinic.org/diseases-conditions/sore-throat/symptoms-causes/syc-20351635. Accessed March 2026.
- NHS staff. Sore Throat. NHS. 8 April 2024. Available from: https://www.nhs.uk/symptoms/sore-throat/. Accessed March 2026.
- Verywell Health staff. How to Soothe a Sore Throat. Verywell Health. 9 December 2025. https://www.verywellhealth.com/how-to-soothe-a-sore-throat-11678457. Accessed March 2026.
- Mayo Clinic Staff. Sore Throat: Diagnosis and Treatment. Mayo Clinic. 12 April 2025. Available from: https://www.mayoclinic.org/diseases-conditions/sore-throat/diagnosis-treatment/drc-20351640. Accessed March 2026.
- Boh M, Gordeev I, Bulc M. A Therapeutic Equivalence of Two Formulations of the Fixed Combination of Benzydamine Hydrochloride and Cetylpyridinium Chloride in the Treatment of Sore Throat Associated with Upper Respiratory Tract. Journal of Clinical Research and Medicine. 22 March 2021. Available from: https://researchopenworld.com/wp-content/uploads/2021/03/JCRM-4-422.pdf. Accessed March 2026.
- Passali D, Arezzo MF, De Rose A, et al. Benzydamine hydrochloride for the treatment of sore throat and irritative/inflammatory conditions of the oropharynx: a cross-national survey among pharmacists and general practitioners. BMC Primary Care. 17 June 2022. Available from: https://link.springer.com/article/10.1186/s12875-022-01762-3. Accessed March 2026.
- iNova Pharmaceuticals (Pty) Ltd. Andolex Analgesic Lozenges Professional Information. South African Health Products Regulatory Authority. 10 December 2020. Available from: https://pi-pil-repository.sahpra.org.za/wp-content/uploads/2025/09/pi-1.pdf. Accessed March 2026.
- Medpharm Staff. The Short and Sweet About iNova’s Andolex-C Lozenges. Medpharm. 23 August 2018. Available from: https://medpharm.co.za/journals/pnt/the-short-and-sweet-about-inovas-andolex-c-lozenges/. Accessed March 2026.
- HPRA. Septabene eucalyptus 3 mg/1 mg lozenges Summary of Product Characteristics. Health Products Regulatory Authority. 13 April 2023. Available from: https://assets.hpra.ie/products/Human/26759/Licence_PA1347-063-001_13042023122632.pdf. Accessed March 2026.
- Nailes JM, Javier RJM, Adversario MPL, et al. Effectiveness of Benzydamine Hydrochloride + Cetylpyridinium Chloride (Difflam®) Lozenges in Alleviating Sore Throat Among COVID-19 Patients: A Real-World Evidence Study in the Clinical Practice. Archives of Infect Diseases & Therapy. 9 June 2023. Available from: https://www.opastpublishers.com/open-access-articles/effectiveness-of-benzydamine-hydrochloride--cetylpyridinium-chloride-difflam-lozenges-in-alleviating-sore-throat-among-c.pdf. Accessed March 2026.
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